発表論文／Papers

2024年

Kakemura B, Igaki T
"Blockade of Crk eliminates Yki/YAP-activated tumors via JNK-mediated apoptosis in Drosophila"
Commun Biol 2024 Sep 28;7(1) [Pubmed]

(Preprint) Akai N, Igaki T and Ohsawa S
"Exocytosis coordinates epithelial cell-turnover in Drosophila ribosomal protein mutants"
bioRxiv 2023 December 28 [Online]

(Preprint) Peterson W et al.
"Flow zoometry of Drosophila"
bioRxiv 2024 April 4 [Online]

Nagata R and *Igaki T.
"Cell competition: emerging signaling and unsolved questions"
FEBS Lett. 2024 Feb;598(4):379-389 [PubMed] (Review)

Kitamura D, Taniguchi K, Nakamura M and *Igaki T.
"In vivo evidence for homeostatic regulation of ribosomal protein levels in Drosophila"
Cell Structure and Function 2024 Jan 16;49(1):11-20. [PubMed]

2023年

*Taniguchi K and *Igaki T.
"Sas-Ptp10D shapes germ-line stem cell niche by facilitating JNK-mediated apoptosis"
PLOS Genetics 2023 Mar 27;19(3):e1010684 [PubMed]

Niwa R, Sato M and Igaki T.
"Editorial note: flying high in Japan"
Fly 2023 Mar 6. [Online] (Editorial)

2022年

Enomoto M and Igaki T.
"Cell-cell interactions that drive tumorigenesis in Drosophila"
Fly 2022 Nov;16(1):367-381. [PubMed] (Review)

Wang Z, Xia X, Li J and Igaki T.
"Tumor elimination by clustered microRNAs miR-306 and miR-79 via non-canonical activation of JNK signaling"
eLife 2022 Oct 12;11:e77340 [PubMed]

Nagata R, Akai N, Kondo S, Saito K, Ohsawa S and Igaki T.
"Yorkie drives supercompetition by non-autonomous induction of autophagy via bantam microRNA in Drosophila"
Current Biology 2022 Feb 07 [PubMed]

　Selected for Faculty Opinions

2021年

Ochi N, Nakamura M, Nagata R, Wakasa N, Nakano R and Igaki T.
"Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2α"
PLOS Genetics 2021 Dec 6;17(12):e1009958 [PubMed]

Cong B, Nakamura M, Sando Y, Kondo T, Ohsawa S and Igaki T.
"JNK and Yorkie drive tumor malignancy by inducing L-amino acid transporter 1 in Drosophila"
PLOS Genetics 2021 Nov 15;17(11):e1009893 [PubMed]

#Enomoto M, Takemoto D and #Igaki T.
"Interaction between Ras and Src clones causes interdependent tumor malignancy via Notch signaling in Drosophila"
Developmental Cell 2021 Aug 9;56(15):2223-2236.e5. [PubMed]

　中国で紹介されました
　京都大学通过果蝇证实，良性肿瘤细胞相邻时会癌变

Wada Y, Ohsawa S and Igaki T.
"Yorkie ensures robust tissue growth in Drosophila ribosomal protein mutants"
Development 2021 Jul 6;dev.198705.[PubMed]

　RESEARCH HIGHLIGHT
　Yki protects Drosophila Minute wing discs from apoptosis

Ito T and Igaki T.
"Yorkie drives Ras-induced tumor progression by microRNA-mediated inhibition of cellular senescence"
Science Signaling 2021 Jun 1;14(685), eaaz3578 [PubMed]

　Selected for Cover of the issue

*Akai N, *#Ohsawa S, Sando Y and #Igaki T.
"Epithelial cell turnover ensures robust coordination of tissue growth in Drosophila ribosomal protein mutants"
PLOS Genetics 2021 Jan 28;17(1):e1009300 [PubMed]

2020年

Kanda H and Igaki T.
"Mechanism of tumor-suppressive cell competition in flies"
Cancer Science 2020 Jul 17; 111:3409-3415 [PubMed] (Review)

Sanaki Y, Nagata R, Kizawa D, Léopold P and Igaki T.
"Hyperinsulinemia drives epithelial tumorigenesis by abrogating cell competition"
Developmental Cell 2020 May 18;53(4):379-389 [PubMed]

　Developmental Cell "Previews" by S. Hirabayashi & R. Cagan,
　Selected for Cover of the issue

　Published as Featured Article
Science Translational Medicine "Editor's choice" by Emily j. Gallagher

2019年

Iida C, Ohsawa S, Taniguchi K, Yamamoto M, Morata G and Igaki T.
"JNK-mediated Slit-Robo signaling facilitates epithelial wound repair by extruding dying cells"
Scientific Reports 2019 Dec 20;9(1) [PubMed]

Nagata R, Nakamura M, Sanaki Y and Igaki T.
"Cell competition is driven by autophagy"
Developmental Cell 2019 Oct 7;51(1):99-112 [PubMed]

　Developmental Cell "Previews" by C. Dillard & T.E. Rusten

2018年

Nagata R and Igaki T.
"Cell competition: Emerging mechanisms to eliminate neighbors"
Dev Growth Differ 2018 [PubMed]（Review）

O'Donnell MA.
"Tatsushi Igaki: Flying up the research summits."
Journal of Cell Biology 2018 [PubMed]

Enomoto M, Siow C and Igaki T.
"Drosophila As a Cancer Model"
Adv Exp Med Biol 2018 [PubMed]

Tsuboi A, Ohsawa S, Umetsu D, Sando Y, Kuranaga E, Igaki T. and Fujimoto K
"Competition for Space Is Controlled by Apoptosis-Induced Change of Local Epithelial Topology"
Current Biology 2018 Jun 11 [PubMed]

Katsukawa M, Ohsawa S, Zhang L, Yan Y and Igaki T.
"Serpin Facilitates Tumor-Suppressive Cell Competition by Blocking Toll-Mediated Yki Activation in Drosophila"
Current Biology 2018 May 15 [PubMed]

Cong B, Ohsawa S and Igaki T.
"JNK and Yorkie drive tumor progression by generating polyploid giant cells in Drosophila."
Oncogene 2018 Mar 14 [PubMed]

Akai N, #Igaki T and #Ohsawa S.
"Wingless signaling regulates winner/loser status in Minute cell competition."
Genes to Cells 2018 Feb 12 [PubMed]

Ohsawa S, Vaughen J and Igaki T.
"Cell Extrusion: A Stress-Responsive Force for Good or Evil in Epithelial Homeostasis."
Developmental Cell 2018 Feb 5;44 (3):284-296 [PubMed] (Review)

2017年

Vaughen J and Igaki T.
"Breaking Down Neighbors to Fuel Tumorigenesis"
Developmental Cell 2017 Feb 6;40 (3):219-220 [PubMed] (Review)

*Yamamoto M, *Ohsawa S, Kunimasa K and Igaki T.
"The ligand Sas and its receptor PTP10D drive tumor-suppressive cell competition"
Nature 2017 Feb 9;542 (7640):246-250 (*equal contribution) [PubMed]

　Science signaling "Editor's choice"

2016年

Vaughen J and Igaki T.
"Slit-Robo Repulsive Signaling Extrudes Tumorigenic Cells from Epithelia"
Developmental Cell 2016 Dec 19;39 (6):683-695 [PubMed]

　Developmental Cell "Previews" by H. Richardson & M. Portela,
　Selected for Cover of the issue
　Selected for F1000 prime
　Selected for Collection: Cancer Cell Biology

Ito T and Igaki T

"Dissecting cellular senescence and SASP in Drosophila"
Inflammation and Regeneration 2016 Sep 17;36:25 [BioMed link](Review)

Nakamura M and Igaki T

"Induction and Detection of Oncogene-Induced Cellular Senescence in Drosophila"
Methods in Molecular Biology 2016, pp211-218 [PubMed]

Ohsawa S and Igaki T

"Non-autonomous Tumor Progression by Oncogenic Inflammation"
Chronic Inflammation 2016, pp211-222 [Springer link] (Review)

Nishikawa S, Takamatsu A, Ohsawa S, Igaki T

"Mathematical model for cell competition: predator-prey interactions at the interface between two groups of cells in monolayer tissue"
J. Theoretical Biology 2016 Sep 7;404:40-50 [PubMed]

2015年

Igaki T

"Communicating the molecular basis of cancer cell-by-cell: an
interview with Tatsushi Igaki"
Disease Models and Mechanisms 2015 8: 1491-1494 [PDF][PubMed] (Interview)

Enomoto M, Vaughen J, Igaki T

"Non-autonomous overgrowth by oncogenic niche cells: cellular cooperatrion and competition in tumorigenesis"
Cancer Science 2015 Sep 12 [PubMed](Review)

Enomoto M, Kizawa D, Ohsawa S, Igaki T

"JNK signaling is coverted from anti- to pro-tumor pathway by Ras-mediated switch of Warts activity"
Developmental Biology 2015 Jul 15;403(2):162-71 [PubMed]

2014年

*Nakamura M, *Ohsawa S, Igaki T
"Mitochondrial defects trigger proliferation of neighbouring cells via a senescence-associated secretory phenotype in Drosophila"
Nature Communications 2014 Oct27;5:5264 [PubMed] (*equal contribution)

*Takino K, *Ohsawa S, Igaki T
"Loss of Rab5 drives non-autonomous cell proliferation through TNF and Ras signaling in Drosophila"
Developmental Biology 2014 Nov 1;395(1):19-28 [PubMed](*equal contribution)

Ohsawa S,Takemoto D, Igaki T
"Dissecting tumor heterogeneity in flies: genetic basis of interclonal oncogenic coorperation"
J. Biochem. 2014 Sep;156(3):129-36 [Pub Med] (Review)

Igaki T, Miura M
"The Drorosophila TNF ortholong Eiger: Emerging physiological roles and evolution of the TNF system."
Semin. Immunol. 2014, S1044-5323 (2014) [Pub Med] (Review)

Kunimasa K, Ohsawa S, Igaki T
"Cell Competition: The Struggle for Existence in Multicellular Communities"
New Principles in Developmental Processes 2014, pp27-40 [Springer Link] (Review)

2013年

Enomoto M, Igaki T
"Src controls tumorigenesis via JNK-dependent regulation of the Hippo pathway in Drosophila"
EMBO Reports 14,65-72(2013) [PubMed]

2012年

Ohsawa S, Sato Y, Enomoto M, Nakamura M, Betsumiya A, Igaki T.
"Mitochondrial defect drives non-autonomous tumor progression through Hippo signaling in Drosophila"
Nature 490, 547-551 (2012) [PubMed]

　Nature Reviews Cancer "Research Highlight",
　Cell "Leading Edge Select",
　Selected for F1000 prime

Ohsawa S, Sugimura K, Takino K, Igaki T.
"Imaging cell competition in Drosophila imaginal discs"
Methods Enzymol. 506, 407-413 (2012) [PubMed]

2011年

Kanda H, Igaki T, Okano H, Miura M
"Conserved metabolic energy production pathways govern Eiger/TNF-induced nonapoptotic cell death."
Proc. Natl. Acad. Sci. USA 108, 18977-18982 (2011) [PubMed]

Enomoto M, Igaki T.
"Deciphering tumor-suppressor signaling in flies: genetic link between Scrib/Dlg/Lgl and the Hippo pathway"
J. Genet. Genom. 38, 461-70 (2011) [PubMed] (Review)

Ohsawa S, Sugimura K, Takino K, Xu T, Miyawaki A, Igaki T.
"Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila"
Developmental Cell 20, 315-328 (2011) [PubMed]

　Nature Reviews Cancer "Research Highlight",
　Science signaling "Editor's Choice",
　Selected for F1000 prime

Igaki T, Kanda H, Okano H, Xu T, Miura M.
"Eiger and wengen: The Drosophila orthologs of TNF/TNFR"
Adv. Exp. Med. Biol. 691, 45-50 (2011) [PubMed] (Review)

2010年

Ohsawa S, Hamada S, Kuida K, Yoshida H, Igaki T, Miura M.
"Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity"
Proc. Natl. Acad. Sci. USA. 107, 13366-13371 (2010) [PubMed]

2009年

Igaki T
“Correcting developmental errors by apoptosis: lessons from Drosophila JNK signaling”
Apoptosis 14, 1021-1028 (2009) [PubMed] (Review)

Igaki T, Pastor-Pareja JC, Aonuma H, Miura M, Xu T.
“Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila”
Developmental Cell 16, 458-465 (2009) [PubMed]

2007年

Xue L, Igaki T, Kuranaga E, Kanda H, Miura M, Xu, T.
"Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila”
Developmental Cell 13, 446-454 (2007) [PubMed]

Srivastava A, Pastor-Pareja JC, Igaki T, Pagliarini R, Xu T.
“Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion”
Proc. Natl. Acad. Sci. USA. 104, 2721-2726 (2007) [PubMed]

*Igaki T, *Suzuki Y, Tokushige N, Aonuma H, **Takahashi R, **Miura M.
“Evolution of mitochondrial cell death pathway: Proapoptotic role of HtrA2/Omi in Drosophila”
Biochem. Biophys. Res. Commun. 356, 993-997 (2007) [PubMed] (*equal contribution)

2006年

Igaki T, Pagliarini R, Xu T
“Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila”
Current Biology 16, 1139-1146 (2006) [PubMed]

2005年

Senoo-Matsuda N, Igaki T, Miura M
“Bax-like protein Drob-1 protects neurons from expanded polyglutamine-induced toxicity in Drosophila”
EMBO J. 24, 2700-2713 (2005) [PubMed]

Kanuka H, Hiratou T, Igaki T, Kanda H, Kuranaga E, Sawamoto K, Aigaki T, Okano H, Miura M
"Gain-of-function screen identifies a role of the Sec61alpha translocon in Drosophila postmitotic neurotoxicity"
Biochim. Biophys. Acta. 1726, 225-237 (2005) [PubMed]

2004年

Igaki T, Miura M
"Role of Bcl-2 family members in invertebrates"
Biochim. Biophys. Acta. 1644, 73-81 (2004) (Review) [PubMed]

2003年

Kanuka H, Kuranaga E, Hiratou T, Igaki T, Nelson B, Okano H, Miura M
"Cytosol-endoplasmic reticulum interplay by Sec61alpha translocon in polyglutamine-mediated neurotoxicity in Drosophila”
Proc. Natl. Acad. Sci. USA 100, 11723-11728 (2003) [PubMed]

2002年

Igaki T, Kanda H, Yamamoto-Goto Y, Kanuka H, Kuranaga E, Aigaki T, Miura M
“Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway”
EMBO J. 21, 3009-3018 (2002) [PubMed]

Igaki T, Yamamoto-Goto Y, Tokushige N, Kanda H, Miura M
“Downregulation of DIAP1 triggers a novel Drosophila cell death pathway mediated by DARK and DRONC.”
J. Biol. Chem. 277, 23103-23106 (2002) [PubMed]

Kuranaga E, Kanuka H, Igaki T, Sawamoto K, Ichijo H, Okano H, Miura M
"Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila.”
Nature Cell Biology 4, 705-10 (2002) [PubMed]

Kanda H, Igaki T, Kanuka H, Yagi T, Miura M
“Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling.”
J. Biol. Chem. 277, 28372-28375 (2002) [PubMed]

2000年

Igaki T, Kanuka H, Inohara N, Sawamoto K, Nunez G, Okano H, Miura M
“Drob-1, a Drosophila member of the Bcl-2/CED-9 family that promotes cell death.”
Proc. Natl. Acad. Sci. USA 97, 662-667 (2000) [PubMed]