発表論文／Papers

* Corresponding author/ 責任著者

Preprint

  • Nakanishi T, Enomoto M, *Igaki T
    ”Iro-C/IRX creates anti-cancerized epithelial field against IL-6-dependent malignant tumorigenesis”
    bioRxiv 2026 Jan 23 [on line]
  • Kakemura B, Kanda H, Matsumoto R, Ueda S, Yasuhara S, Nagata R, Taniguchi K, Kondo S, Miyoshi K, Kobayashi T, Takeuchi K, Saito K, Matsuyama M, Murakawa Y and *Igaki T
    "Cellular fitness is determined by ribosomal protein S12-mediated release of a truncated Xrp1"
    bioRxiv 2025 Oct 30 [on line]
  • Peterson W et al.
    "Flow zoometry of Drosophila"
    bioRxiv 2024 Apr 4 [on line]

2025年

  • Hirooka E, Hattori R, Ikawa K, Kobayashi T, Matsuyama M, Igaki T, *Ohsawa S
    "Macrophages promote tumor growth by phagocytosis-mediated cytokine amplification in Drosophoila"
    Curr Biol. 2025 July 25:S0960-9822(25)00961-3 [Pubmed]
  • Akai N, Igaki T and *Ohsawa S
    "Exocytosis coordinates epithelial cell-turnover in Drosophila ribosomal protein mutants"
    iScience 2025 May 5;28(6):112587 [Pubmed]
  • Li J, Taniguchi K, Ye W, Kondo S, Kobayashi T, Matsuyama M, Saito K, Ohsawa S and *Igaki T
    "Epithelial cell-fate switch triggering ectopic ligand-receptor-mediated JAK-STAT signaling promotes tumorigenesis in Drosophila"
    iScience 2025 Mar 10;28(4):112191 [Pubmed]
  • Zang Y, Yoshimoto M and *Igaki T
    "Programmed cell senescence is required for sensory organ development in Drosophila"
    iScience 2025 Mar 21;28 (3) [Pubmed]
  • *Goda K, Igaki T, Kuhn B, Mizushima N, Nagai T, Nakagawa A, Osumi N, Shen A, Sonoshita M and Yanagisawa M
    "Japan can be a science heavyweight once more — if it rethinks funding"
    Nature 2025 Feb 11;638(8050):318-320 [Pubmed]

2024年

  • Kakemura B, and *Igaki T
    "Blockade of Crk eliminates Yki/YAP-activated tumors via JNK-mediated apoptosis in Drosophila"
    Commun Biol 2024 Sep 28;7(1) [Pubmed]
  • Nagata R and *Igaki T.
    "Cell competition: emerging signaling and unsolved questions"
    FEBS Lett. 2024 Feb;598(4):379-389 [PubMed] (Review)
  • Kitamura D, Taniguchi K, Nakamura M and *Igaki T.
    "In vivo evidence for homeostatic regulation of ribosomal protein levels in Drosophila"
    Cell Structure and Function 2024 Jan 16;49(1):11-20. [PubMed]

2023年

  • *Taniguchi K and *Igaki T.
    "Sas-Ptp10D shapes germ-line stem cell niche by facilitating JNK-mediated apoptosis"
    PLOS Genetics 2023 Mar 27;19(3):e1010684 [PubMed]
  • *Niwa R, Sato M and Igaki T.
    "Editorial note: flying high in Japan"
    Fly 2023 Mar 6. [Pubmed] (Editorial)

2022年

  • Enomoto M and Igaki T.
    "Cell-cell interactions that drive tumorigenesis in Drosophila"
    Fly 2022 Nov;16(1):367-381. (Review)
  • Wang Z, Xia X, Li J and Igaki T.
    "Tumor elimination by clustered microRNAs miR-306 and miR-79 via non-canonical activation of JNK signaling"
    eLife 2022 Oct 12;11:e77340 [PubMed]
  • Nagata R, Akai N, Kondo S, Saito K, Ohsawa S and Igaki T.
    "Yorkie drives supercompetition by non-autonomous induction of autophagy via bantam microRNA in Drosophila"
    Current Biology 2022 Feb 07 [PubMed]
    • Selected for Faculty Opinions [on line]

2021年

  • Ochi N, Nakamura M, Nagata R, Wakasa N, Nakano R and Igaki T.
    "Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2α"
    PLOS Genetics 2021 Dec 6;17(12):e1009958 [PubMed]
  • Cong B, Nakamura M, Sando Y, Kondo T, Ohsawa S and Igaki T.
    "JNK and Yorkie drive tumor malignancy by inducing L-amino acid transporter 1 in Drosophila"
    PLOS Genetics 2021 Nov 15;17(11):e1009893 [PubMed]
  • *Enomoto M, Takemoto D and *Igaki T.
    "Interaction between Ras and Src clones causes interdependent tumor malignancy via Notch signaling in Drosophila"
    Developmental Cell 2021 Aug 9;56(15):2223-2236.e5. [PubMed]
  • Wada Y, Ohsawa S and Igaki T.
    "Yorkie ensures robust tissue growth in Drosophila ribosomal protein mutants"
    Development 2021 Jul 6;dev.198705.[PubMed]
  • Ito T and Igaki T.
    "Yorkie drives Ras-induced tumor progression by microRNA-mediated inhibition of cellular senescence"
    Science Signaling 2021 Jun 1;14(685), eaaz3578 [PubMed]
    • Selected for Cover of the issue
  • #Akai N, *#Ohsawa S, Sando Y and #Igaki T.
    "Epithelial cell turnover ensures robust coordination of tissue growth in Drosophila ribosomal protein mutants"
    PLOS Genetics 2021 Jan 28;17(1):e1009300 [PubMed]

2020年

  • Kanda H and Igaki T.
    "Mechanism of tumor-suppressive cell competition in flies"
    Cancer Science 2020 Jul 17; 111:3409-3415 [PubMed] (Review)
  • Sanaki Y, Nagata R, Kizawa D, Léopold P and* Igaki T.
    "Hyperinsulinemia drives epithelial tumorigenesis by abrogating cell competition"
    Developmental Cell 2020 May 18;53(4):379-389 [PubMed]
    • Developmental Cell "Previews" by S. Hirabayashi & R. Cagan,
      Selected for Cover of the issue
    • Published as Featured Article
      Science Translational Medicine "Editor's choice" by Emily j. Gallagher

2019年

  • Iida C, Ohsawa S, Taniguchi K, Yamamoto M, Morata G and *Igaki T.
    "JNK-mediated Slit-Robo signaling facilitates epithelial wound repair by extruding dying cells"
    Scientific Reports 2019 Dec 20;9(1) [PubMed]
  • Nagata R, Nakamura M, Sanaki Y and *Igaki T.
    "Cell competition is driven by autophagy"
    Developmental Cell 2019 Oct 7;51(1):99-112 [PubMed]
    • Developmental Cell "Previews" by C. Dillard & T.E. Rusten

2018年

  • Nagata R and Igaki T.
    "Cell competition: Emerging mechanisms to eliminate neighbors"
    Dev Growth Differ 2018 [PubMed]（Review）
  • O'Donnell MA.
    "Tatsushi Igaki: Flying up the research summits."
    Journal of Cell Biology 2018 [PubMed]
  • Enomoto M, Siow C and Igaki T.
    "Drosophila As a Cancer Model"
    Adv Exp Med Biol 2018 [PubMed]
  • Tsuboi A, Ohsawa S, Umetsu D, Sando Y, Kuranaga E, Igaki T. and Fujimoto K
    "Competition for Space Is Controlled by Apoptosis-Induced Change of Local Epithelial Topology"
    Current Biology 2018 Jun 11 [PubMed]
  • Katsukawa M, Ohsawa S, Zhang L, Yan Y and Igaki T.
    "Serpin Facilitates Tumor-Suppressive Cell Competition by Blocking Toll-Mediated Yki Activation in Drosophila"
    Current Biology 2018 May 15 [PubMed]
  • Cong B, Ohsawa S and Igaki T.
    "JNK and Yorkie drive tumor progression by generating polyploid giant cells in Drosophila."
    Oncogene 2018 Mar 14 [PubMed]
  • Akai N, #Igaki T and #Ohsawa S.
    "Wingless signaling regulates winner/loser status in Minute cell competition."
    Genes to Cells 2018 Feb 12 [PubMed]
  • Ohsawa S, Vaughen J and Igaki T.
    "Cell Extrusion: A Stress-Responsive Force for Good or Evil in Epithelial Homeostasis."
    Developmental Cell 2018 Feb 5;44 (3):284-296 [PubMed] (Review)

2017年

  • Vaughen J and Igaki T.
    "Breaking Down Neighbors to Fuel Tumorigenesis"
    Developmental Cell 2017 Feb 6;40 (3):219-220 [PubMed] (Review)
  • *Yamamoto M, *Ohsawa S, Kunimasa K and Igaki T.
    "The ligand Sas and its receptor PTP10D drive tumor-suppressive cell competition"
    Nature 2017 Feb 9;542 (7640):246-250 (*equal contribution) [PubMed]

2016年

  • Vaughen J and Igaki T.
    "Slit-Robo Repulsive Signaling Extrudes Tumorigenic Cells from Epithelia"
    Developmental Cell 2016 Dec 19;39 (6):683-695 [PubMed]
  • Ito T and Igaki T
    "Dissecting cellular senescence and SASP in Drosophila"
    Inflammation and Regeneration 2016 Sep 17;36:25 [BioMed link](Review)
  • Nakamura M and Igaki T
    "Induction and Detection of Oncogene-Induced Cellular Senescence in Drosophila"
    Methods in Molecular Biology 2016, pp211-218 [PubMed]
  • Ohsawa S and Igaki T
    "Non-autonomous Tumor Progression by Oncogenic Inflammation"
    Chronic Inflammation 2016, pp211-222 [Springer link] (Review)
  • Nishikawa S, Takamatsu A, Ohsawa S, Igaki T
    "Mathematical model for cell competition: predator-prey interactions at the interface between two groups of cells in monolayer tissue"
    J. Theoretical Biology 2016 Sep 7;404:40-50 [PubMed]

2015年

  • Igaki T
    "Communicating the molecular basis of cancer cell-by-cell: an
    interview with Tatsushi Igaki"
    Disease Models and Mechanisms 2015 8: 1491-1494 [PDF] (Interview)
  • Enomoto M, Vaughen J, Igaki T
    "Non-autonomous overgrowth by oncogenic niche cells: cellular cooperatrion and competition in tumorigenesis"
    Cancer Science 2015 Sep 12 [PubMed](Review)
  • Enomoto M, Kizawa D, Ohsawa S, Igaki T
    "JNK signaling is coverted from anti- to pro-tumor pathway by Ras-mediated switch of Warts activity"
    Developmental Biology 2015 Jul 15;403(2):162-71 [PubMed]

2014年

  • *Nakamura M, *Ohsawa S, Igaki T
    "Mitochondrial defects trigger proliferation of neighbouring cells via a senescence-associated secretory phenotype in Drosophila"
    Nature Communications 2014 Oct27;5:5264 [PubMed] (*equal contribution)
  • *Takino K, *Ohsawa S, Igaki T
    "Loss of Rab5 drives non-autonomous cell proliferation through TNF and Ras signaling in Drosophila"
    Developmental Biology 2014 Nov 1;395(1):19-28 [PubMed](*equal contribution)
  • Ohsawa S,Takemoto D, Igaki T
    "Dissecting tumor heterogeneity in flies: genetic basis of interclonal oncogenic coorperation"
    J. Biochem. 2014 Sep;156(3):129-36 [Pub Med] (Review)
  • Igaki T, Miura M
    "The Drorosophila TNF ortholong Eiger: Emerging physiological roles and evolution of the TNF system."
    Semin. Immunol. 2014, S1044-5323 (2014) [Pub Med] (Review)
  • Kunimasa K, Ohsawa S, Igaki T
    "Cell Competition: The Struggle for Existence in Multicellular Communities"
    New Principles in Developmental Processes 2014, pp27-40 [Springer Link] (Review)

2013年

  • Enomoto M, Igaki T
    "Src controls tumorigenesis via JNK-dependent regulation of the Hippo pathway in Drosophila"
    EMBO Reports 14,65-72(2013) [PubMed]

2012年

  • Ohsawa S, Sato Y, Enomoto M, Nakamura M, Betsumiya A, Igaki T.
    "Mitochondrial defect drives non-autonomous tumor progression through Hippo signaling in Drosophila"
    Nature 490, 547-551 (2012) [PubMed]
  • Ohsawa S, Sugimura K, Takino K, Igaki T.
    "Imaging cell competition in Drosophila imaginal discs"
    Methods Enzymol. 506, 407-413 (2012) [PubMed]

2011年

  • Kanda H, Igaki T, Okano H, Miura M
    "Conserved metabolic energy production pathways govern Eiger/TNF-induced nonapoptotic cell death."
    Proc. Natl. Acad. Sci. USA 108, 18977-18982 (2011) [PubMed]
  • Enomoto M, Igaki T.
    "Deciphering tumor-suppressor signaling in flies: genetic link between Scrib/Dlg/Lgl and the Hippo pathway"
    J. Genet. Genom. 38, 461-70 (2011) [PubMed] (Review)
  • Ohsawa S, Sugimura K, Takino K, Xu T, Miyawaki A, Igaki T.
    "Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila"
    Developmental Cell 20, 315-328 (2011) [PubMed]
  • Igaki T, Kanda H, Okano H, Xu T, Miura M.
    "Eiger and wengen: The Drosophila orthologs of TNF/TNFR"
    Adv. Exp. Med. Biol. 691, 45-50 (2011) [PubMed] (Review)

2010年

  • Ohsawa S, Hamada S, Kuida K, Yoshida H, Igaki T, Miura M.
    "Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity"
    Proc. Natl. Acad. Sci. USA. 107, 13366-13371 (2010) [PubMed]a

2009年

  • Igaki T
    “Correcting developmental errors by apoptosis: lessons from Drosophila JNK signaling”
    Apoptosis 14, 1021-1028 (2009) [PubMed] (Review)
  • Igaki T, Pastor-Pareja JC, Aonuma H, Miura M, Xu T.
    “Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila”
    Developmental Cell 16, 458-465 (2009) [PubMed]

2007年

  • Xue L, Igaki T, Kuranaga E, Kanda H, Miura M, Xu, T.
    "Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila”
    Developmental Cell 13, 446-454 (2007) [PubMed]
  • Srivastava A, Pastor-Pareja JC, Igaki T, Pagliarini R, Xu T.
    “Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion”
    Proc. Natl. Acad. Sci. USA. 104, 2721-2726 (2007) [PubMed]
  • *Igaki T, *Suzuki Y, Tokushige N, Aonuma H, **Takahashi R, **Miura M.
    “Evolution of mitochondrial cell death pathway: Proapoptotic role of HtrA2/Omi in Drosophila”
    Biochem. Biophys. Res. Commun. 356, 993-997 (2007) [PubMed] (*equal contribution)

2006年

  • Igaki T, Pagliarini R, Xu T
    “Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila”
    Current Biology 16, 1139-1146 (2006) [PubMed]

2005年

  • Senoo-Matsuda N, Igaki T, Miura M
    “Bax-like protein Drob-1 protects neurons from expanded polyglutamine-induced toxicity in Drosophila”
    EMBO J. 24, 2700-2713 (2005) [PubMed]
  • Kanuka H, Hiratou T, Igaki T, Kanda H, Kuranaga E, Sawamoto K, Aigaki T, Okano H, Miura M
    "Gain-of-function screen identifies a role of the Sec61alpha translocon in Drosophila postmitotic neurotoxicity"
    Biochim. Biophys. Acta. 1726, 225-237 (2005) [PubMed]

2004年

  • Igaki T, Miura M
    "Role of Bcl-2 family members in invertebrates"
    Biochim. Biophys. Acta. 1644, 73-81 (2004) (Review) [PubMed]

2003年

  • Kanuka H, Kuranaga E, Hiratou T, Igaki T, Nelson B, Okano H, Miura M
    "Cytosol-endoplasmic reticulum interplay by Sec61alpha translocon in polyglutamine-mediated neurotoxicity in Drosophila”
    Proc. Natl. Acad. Sci. USA 100, 11723-11728 (2003) [PubMed]

2002年

  • Igaki T, Kanda H, Yamamoto-Goto Y, Kanuka H, Kuranaga E, Aigaki T, Miura M
    “Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway”
    EMBO J. 21, 3009-3018 (2002) [PubMed]
  • Igaki T, Yamamoto-Goto Y, Tokushige N, Kanda H, Miura M
    “Downregulation of DIAP1 triggers a novel Drosophila cell death pathway mediated by DARK and DRONC.”
    J. Biol. Chem. 277, 23103-23106 (2002) [PubMed]
  • Kuranaga E, Kanuka H, Igaki T, Sawamoto K, Ichijo H, Okano H, Miura M
    "Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila.”
    Nature Cell Biology 4, 705-10 (2002) [PubMed]
  • Kanda H, Igaki T, Kanuka H, Yagi T, Miura M
    “Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling.”
    J. Biol. Chem. 277, 28372-28375 (2002) [PubMed]

2000年

  • Igaki T, Kanuka H, Inohara N, Sawamoto K, Nunez G, Okano H, Miura M
    “Drob-1, a Drosophila member of the Bcl-2/CED-9 family that promotes cell death.”
    Proc. Natl. Acad. Sci. USA 97, 662-667 (2000) [PubMed]

和文総説 / Reviews in Japanese

特許 / Patent

  • Xu T, Pagliarini R, Igaki T
    “A genetic screen in Drosophila for metastatic behavior”
    United States Patent 20060288429 (2006)
  • Xu T, Pagliarini R, Igaki T
    “A genetic screen in Drosophila for metastatic behavior”
    International Patent WO 2005/035729 A3 (2005)
    International Publication Date: April 21 (2005)

受賞歴 / Awards

報道 / Report

学会発表 / Conference Presentations